However, the current public perception of genetics is that it provides “yes/no” answers about the presence/absence of a condition, or the potential for developing a condition, which in not the case for common, complex disorders with polygenic architecture. Public engagement is therefore becoming important on the potential use and acceptability of PRSs. Although PRSs are unlikely ever to be fully diagnostic, they may give valuable medical information for risk stratification, prognosis, or treatment response prediction. As genome-wide association studies increase in power, the predictive ability for disease risk will also increase. They can be calculated in any genome-wide genotype data-source, using a prediction model based on genome-wide summary statistics from external studies. Polygenic risk scores (PRSs) give a single measure of disease liability by summarizing disease risk across hundreds of thousands of genetic variants. To date, interpretation of genomic information has focused on single variants conferring disease risk, but most disorders of major public concern have a polygenic architecture. 5Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.4Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.3Department of Medical & Molecular Genetics, Faculty of Life Sciences & Medicine, King’s College London, London, United Kingdom.

2Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom.1Institute of Biological Psychiatry, Mental Health Centre Sankt Hans, Copenhagen, Denmark.Lasse Folkersen 1*, Oliver Pain 2, Andrés Ingason 1, Thomas Werge 1†, Cathryn M.

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